The book unfolds through a series of letters exchanged among various exceptionally sensitive heroines, beginning with Laura recounting her youth in Wales. Laura relates how she met and immediately married the noble Edward, who had fled his mercenary father to escape a forced match with Lady Dorothea. Following this hasty union, Laura and Edward take refuge with Edward's friends Augustus and Sophia, a couple whose devotion is matched only by their extravagant disdain for financial realities.
As the narrative progresses, the characters lurch from one crisis to another, frequently overcome by swoons and frantic fits whenever faced with the smallest inconvenience or distress. Augustus is arrested for debt, leading to a frantic series of journeys where Laura and Sophia seek aid from various relatives, including a wealthy grandfather who dispenses modest banknotes before abruptly vanishing. Along the way, the heroines take it upon themselves to rescue young Janetta from an unwanted suitor by orchestrating a clandestine elopement, demonstrating their unwavering commitment to romantic impulse over parental authority.
The characters' absolute devotion to sensibility leads to repeated financial thefts, abandonments, and melodramatic declarations. Tragedy strikes when Edward and Augustus are overturned in a high phaeton and succumb to their injuries, prompting fresh rounds of dramatic fainting and raving. Sophia soon follows her husband into the grave after falling ill from a cold caught during a previous swoon.
The narrative concludes with Laura finding herself unexpectedly reunited with all her surviving acquaintances in a Scottish stagecoach. Despite her various trials, she accepts a modest annuity from Sir Edward and retires to a remote Highland village to indulge in perpetual, uninterrupted solitude and lamentation, remaining entirely unrepentant of the absurd emotional excesses that defined her adventures.