The narrative begins in the forgotten medieval town of Eschenbach, where the weaver Gottfried Nothafft quietly hoards money to secure a future for his young son, Daniel. Haunted by the rise of industrial machinery which destroys his livelihood, Gottfried leaves a legacy of hidden capital with his brother-in-law, the ambitious bookseller Jason Philip Schimmelweis, before passing away. Daniel grows up into a fiercely rebellious, difficult boy who displays an absolute indifference to traditional schooling, caring only for the music that haunts his imagination. Supported by a sympathetic music teacher named Spindler, Daniel flees his mother and relatives multiple times to pursue his calling, enduring extreme poverty, harsh labor, and bitter disappointment in his encounters with musical authorities.
Moving to Nuremberg, Daniel plunges deeper into bohemian squalor, associating with a motley group of destitute dreamers while stubbornly clinging to his artistic ideals. Despite his utter destitution and social alienation, he finds rare kindred spirits in the compassionate scientist Friedrich Benda and the enigmatic young Eleanore Jordan. His struggles culminate in a disastrous public rehearsal of his orchestral works, where his perfectionism boils over into an explosive confrontation with the established conductor, Andreas Döderlein. Though his music shows profound genius, his defiant refusal to conform to societal expectations brings him into sharp conflict with his family and mentors, particularly the manipulative Jason Philip.
As the years pass, Daniel takes on the grueling work of a traveling opera conductor in the provinces, continually warring against incompetence, philistinism, and his own internal demons. His relationships with women—ranging from a tragic encounter with a destitute singer to his complex bond with the pious Gertrude and the independent Eleanore—mirror his tortured relationship with the world. He remains an outcast by choice, guarding his creative fire against a society that demands compromise. The novel traces his relentless trajectory toward a destiny defined entirely by artistic integrity and unyielding spiritual resolve.