The story opens in Paris in eighteen forty-seven at the posthumous furniture sale of Marguerite Gautier, a famous courtesan who died of consumption. The narrator, Alexandre, buys a copy of Manon Lescaut inscribed by a young man named Armand Duval. Later, Armand visits Alexandre to reclaim the book and shares the tragic tale of his love affair with Marguerite. Armand had fallen in love with Marguerite at first sight, and she eventually left her lavish life of dissipation and her wealthy protectors to live quietly with him in the country.
Their idyllic pastoral romance is threatened by mounting debts and the stern intervention of Armand’s father, who demands that Marguerite sacrifice her happiness to preserve his family's honour and his daughter's prospective marriage. Pressured by this paternal appeal and her own failing health, Marguerite secretly leaves Armand and returns to her former life. Blinded by jealousy and grief, Armand cruelly persecutes her until the truth is finally revealed too late. Marguerite dies alone in Paris, consumed by illness and heartbreak, leaving behind a written confession for Armand that lays bare the depth of her sacrifice and enduring love.