The novel opens with Herbert Brande declaring the universe to be a colossal mistake, setting the stage for a chilling scientific crusade. Brande, a brilliant but unhinged physicist, leads the Cui Bono Society, an esoteric group dedicated to investigating the origins of existence through radical and terrifying experiments. Arthur Marcel, the narrator, is drawn into this dark world not by scientific curiosity, but by his deepening fascination with Brande's sister, Natalie. As Marcel navigates the intellectual tyranny of the Society, he uncovers a sinister truth: former members who attempt to leave die mysteriously, effectively turning the organization into a fatal cult.
Brande's ambition scales from microscopic demonstrations of atomic disintegration to a grand design for planetary annihilation. He constructs an elaborate narrative around the inherent cruelty of nature, arguing that suffering is the bedrock of all material existence and that the only true mercy is a return to the primal ether. Despite Marcel's growing dread and his desperate attempts to protect Natalie from her brother's psychological domination, the plot gathers irreversible momentum. The narrative shifts from intellectual debate to physical peril as Brande transports his followers to a remote island to execute the final phase of his master plan.
In a desperate bid to thwart the catastrophe, Marcel secretly tampers with Brande's complex mathematical formula and administers a debilitating drug to blunt the scientist's telepathic reach. Yet, despite these interventions, the physical machinery of destruction cannot be entirely halted. The resulting cataclysm obliterates the island, leaving Marcel and a handful of survivors to grapple with the tragic cost of fanaticism. The novel closes on a sombre note of psychological desolation, as Marcel reflects on the irrevocable loss of Natalie and the haunting realization that human struggles against the cosmos are ultimately futile.