The narrative begins with the death of Philip and the rapid consolidation of Alexander's power in Greece. Following early military operations against the Thracians, Triballians, and Illyrians, Alexander subdues the rebellion at Thebes and crosses the Hellespont into Asia. His initial encounters with the Persian forces culminate in the decisive battle at the Granicus River, where Macedonian discipline overcomes the vast numbers of the Persian cavalry. The campaign proceeds through Sardis, Ephesus, Miletus, and the arduous siege of Halicarnassus, steadily dismantling Persian maritime power by capturing coastal strongholds.
As the campaign advances inland, Alexander confronts Darius in the major engagements at Issus and Gaugamela. The battle of Issus results in a significant Persian rout and the capture of the royal family, prompting a protracted siege of Tyre to secure the coastline before pushing southward into Egypt. In Egypt, Alexander founds Alexandria and consults the oracle of Ammon. The subsequent pursuit of Darius leads deep into the interior of Asia, marked by the crossing of the Euphrates and Tigris rivers and the eventual collapse of the Persian Empire.
The later phases of the text document the consolidation of power through Central Asia, the pursuit and assassination of Darius by Bessus, and the subsequent subjugation of Bactria and Sogdiana. Alexander faces internal conspiracies, notably the trials of Philotas and Parmenio, while continually pushing his forces across difficult terrain and harsh climates. The narrative details ongoing military operations against various nomad tribes and mountain strongholds, illustrating the immense logistical and strategic challenges of governing a rapidly expanding empire.