The work begins by exploring the dual nature of true wisdom, which consists of the knowledge of God and the knowledge of oneself. Calvin argues that humanity naturally possesses a rudimentary sense of the divine, yet this innate seed is continually corrupted by ignorance, pride, and intentional wickedness. Because the creation serves as a mirror reflecting divine glory but is ultimately obscured by human blindness, the author insists that scripture must act as the primary guide to lead seekers to the true Creator. The text then establishes the unity of the divine essence and the trinity of persons, proving the eternal deity of both the Son and the Holy Spirit through extensive biblical proof.
Moving from creation to the fallen state of humanity, the argument demonstrates that Adam's defection plunged all mankind into original sin, stripping humanity of free will and rendering every human action subject to condemnation. To rescue lost humanity, redemption must be sought exclusively in Christ, who fulfills the threefold office of prophet, king, and priest. The text examines the moral law, demonstrating that its purpose was not to offer salvation by works, but to encourage hope in Christ until his revelation in the gospel.
Calvin then details the manner in which the grace of Christ is received through the secret operation of the Holy Spirit, defining faith, repentance, and the life of a Christian. Justification by faith alone is defended as the chief benefit of this union, emphasizing that human beings possess no inherent righteousness and must rely entirely on divine grace. The discussion extends to eternal election, the final resurrection, and the establishment of the church, emphasizing the pure preaching of the word and the proper administration of the sacraments as the sole true marks of the visible church. Finally, civil government is addressed as a signal blessing ordained by God for the preservation of human society until the heavenly inheritance is attained.