The narrative opens with Cyrus the Younger gathering a massive mercenary force, including ten thousand Greeks, to wrest the Persian throne from his brother Artaxerxes. The march penetrates deep into the Asian continent under false pretenses before the true objective is revealed at the Euphrates. At the fateful Battle of Cunaxa, Cyrus is slain just as his Greek mercenaries rout the royal wing facing them, leaving the expedition stranded in hostile territory without a patron.
Following the battle, the Persian satrap Tissaphernes lures the Greek generals into a treacherous parley and executes them. Leaderless, isolated, and thousands of miles from home, the mercenary army descends into despair. Xenophon emerges as a central figure, rallying the demoralized soldiers and helping to restructure the command echelon to lead the desperate retreat northward.
The core of the work follows this grueling epic journey through the uncharted highlands of the Carduchians, Armenia, and the snowy wastes of Anatolia. The Greeks face constant harassment from hostile tribes, treacherous terrain, severe winter elements, and lack of provisions, relying on strict discipline and tactical innovation to survive.
Throughout the march, Xenophon details the complex geopolitical landscape, local customs, and the psychological endurance of the soldiers. The tension mounts as internal factions threaten to dissolve the army while external foes continually test their flanks. The resolution offers a hard-won triumph as the bedraggled host finally sights the Black Sea, erupting in the famous cry of joy and reaching safety in Greek colonial territory.